Temporal dynamics of recovery from extinction shortly after extinction acquisition

Abstract

Evidence suggests that extinction is new learning. Memory acquisition involves both short-term memory (STM) and long-term memory (LTM) components; however, few studies have examined early phases of extinction retention. Retention of auditory fear extinction was examined at various time points. Shortly (1-4 h) after extinction acquisition spontaneous recovery was high compared to that after longer delays (8-24 h). Recall of a consolidated extinction trace was also impaired if it was preceded 1 h by extinction of a novel CS; propranolol did not attenuate this effect. These results suggest poor extinction retention reflects a retrieval impairment caused by the aversive experience of extinction training.