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. 2013 Sep 3;109(5):1287-90.
doi: 10.1038/bjc.2013.381. Epub 2013 Jul 16.

Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study

S Beiggi  1 , J B Johnston, M D Seftel, M W Pitz, R Kumar, V Banerji, E J Griffith, S B Gibson
Affiliations

Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study

S Beiggi et al. Br J Cancer. .

Abstract

Background: Chronic lymphocytic leukaemia (CLL) patients have an increased risk of other malignancies. This may be due to surveillance bias, treatment or immunosuppression.

Methods: Cohort study of 612 consecutively diagnosed CLL patients in a Canadian province, with comparisons to follicular lymphoma (FL) patients.

Results: Treated CLL patients had a 1.7-fold increased risk of second cancers compared with untreated CLL patients. As compared with untreated FL patients, untreated CLL patients had a two-fold increased incidence of second malignancies.

Conclusion: Chronic lymphocytic leukaemia patients have an inherent predisposition to second cancers and the incidence is further increased by treatment.

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Figures

Figure 1
Figure 1
Site-specific incidence rates of second malignancies in CLL patients as compared with FL patients and the general population of Manitoba, by gender. Unadjusted incidence rates are calculated from 1998 to 2009 and are expressed per 100 000 persons. CLL=chronic lymphocytic leukaemia; F=female; FL=follicular lymphoma; GP=general population; M=male.
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