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. 2013 Oct;13(10):1308-13.
doi: 10.1002/mabi.201300117. Epub 2013 Jul 16.

Calcium-mediated secondary cross-linking of bisphosphonated oligo(poly(ethylene glycol) fumarate) hydrogels

M Reza Nejadnik  1 , Xia Yang, Tokio Mimura, Zeinab Tahmasebi Birgani, Pamela Habibovic, Kiyoshi Itatani, John A Jansen, Jons Hilborn, Dmitri Ossipov, Antonios G Mikos, Sander C G Leeuwenburgh
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Calcium-mediated secondary cross-linking of bisphosphonated oligo(poly(ethylene glycol) fumarate) hydrogels

M Reza Nejadnik et al. Macromol Biosci. 2013 Oct.

Abstract

This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg(2+) and Ca(2+). More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers.

Keywords: bisphosphonates; calcium-binding; coordination bonds; hydrogels; metal-polymer complexes.

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