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. 2013 Sep;15(9):1244-50.
doi: 10.1093/neuonc/not092. Epub 2013 Jul 16.

Co-polysomy of chromosome 1q and 19p predicts worse prognosis in 1p/19q codeleted oligodendroglial tumors: FISH analysis of 148 consecutive cases

Xiaohui Ren  1 , Haihui Jiang, Xiangli Cui, Yong Cui, Jun Ma, Zhongli Jiang, Dali Sui, Song Lin
Affiliations

Co-polysomy of chromosome 1q and 19p predicts worse prognosis in 1p/19q codeleted oligodendroglial tumors: FISH analysis of 148 consecutive cases

Xiaohui Ren et al. Neuro Oncol. 2013 Sep.

Abstract

Background: This study aimed to evaluate the prognostic significance of co-polsomy of chromosome 1q and 19p in 1p/19q codeleted oligodendroglial tumors (ODGs).

Methods: In a series of 148 ODGs with 1p/19q deletion, co-polysomy of 1q and 19p was detected by fluorescence in situ hybridization (FISH). Log-rank analysis and Cox regression methods were used to compare Kaplan-Meier plots and identify factors associated with worse prognosis.

Results: There were 104 (70.3%) low-grade ODGs and 44 (29.7%) high-grade ODGs. Co-polysomy was independently associated with shorter progression-free survival and overall survival in 1p/19q codeleted ODGs, irrespective of tumor grades. The odds ratio of without and with co-polysomy was 0.263 (95% confidence interval [CI], 0.089-0.771; P = .015) for progression-free survival and 0.213 (95% CI, 0.060-0.756; P = .017) for overall survival. Subgroup analysis confirmed this trend in both low-grade and high-grade ODGs, although the P value for high-grade ODGs was marginally significant.

Conclusions: Co-polysomy of 1q and 19p could be used as a marker to independently predict worse prognoses and guide individual therapy in 1p/19q codeleted ODGs.

Keywords: 1p/19q co-deletion; co-polysomy; oligodendroglial tumors; prognosis; survival.

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Figures

Fig. 1.
Fig. 1.
Patients with 1p/19q codeleted ODGs with co-polysomy have significantly shorter PFS (A, P = .001) and OS (C, P = .008) than do those without co-polysomy. Patients with 1p/19q codeleted ODGs with grade III have shorter PFS (B, P = .004) and OS (D, P = .018) than do those with grade II.
Fig. 2.
Fig. 2.
The PFS and OS of 1p/19q codeleted low-grade ODGs with co-polysomy are significantly shorter than those of 1p/19q codeleted low-grade ODGs without co-polysomy (A, P = .011 and B, P = .009). The PFS and OS of 1p/19q codeleted high-grade ODGs with co-polysomy show a trend to be shorter than those of 1p/19q codeleted high-grade ODGs without co-polysomy, although the difference is marginally significant (C, P = .109 and D, P = .353).
See this image and copyright information in PMC

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