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Case Reports
. 2011 Jul 25:3:21-4.
doi: 10.4137/OED.S7300. Print 2011.

Central corneal melting associated with reformulated generic diclofenac in a patient with inferior fornix foreshortening

Cameron Campbell Johnson  1
Affiliations
Case Reports

Central corneal melting associated with reformulated generic diclofenac in a patient with inferior fornix foreshortening

Cameron Campbell Johnson. Ophthalmol Eye Dis. .

Abstract

Purpose: To report a case of corneal melting in a patient with fornix foreshortening being treated with reformulated generic diclofenac.

Methods: Case report.

Results: An asymptomatic 76-year old man presented with central corneal melting while being treated with reformulated generic diclofenac. This formulation did not contain the vitamin E derivative, tocophersolan, which has been felt to contribute to corneal melting associated with generic diclofenac in the past. Other factors for corneal melting included multiple medication use and altered forniceal architecture, but did not include previous corneal or cataract surgery. Following discontinuation of the topical medications and temporary tarsorrhapy, the defect reepithelialized.

Conclusion: In patients with a compromised ocular surface, reformulated generic diclofenac has the potential to cause corneal melting without prior cataract or refractive surgery. Use should not be indiscriminate or without close supervision.

Keywords: NSAID; corneal melting; corneal ulcer; diclofenac.

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Figures

Figure 1
Figure 1
Left eye at presentation showing a central corneal melt.
Figure 2
Figure 2
Foreshortening of the patient’s inferior fornix.
See this image and copyright information in PMC

References

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