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. 2013:2013:215391.
doi: 10.1155/2013/215391. Epub 2013 Jun 4.

Influence of the toothpaste with brazilian ethanol extract propolis on the oral cavity health

Dariusz Skaba  1 , Tadeusz Morawiec, Marta Tanasiewicz, Anna Mertas, Elżbieta Bobela, Ewelina Szliszka, Małgorzata Skucha-Nowak, Monika Dawiec, Rindai Yamamoto, Shinobu Ishiai, Yuki Makita, Małgorzata Redzynia, Beata Janoszka, Iwona Niedzielska, Wojciech Król
Affiliations

Influence of the toothpaste with brazilian ethanol extract propolis on the oral cavity health

Dariusz Skaba et al. Evid Based Complement Alternat Med. 2013.

Abstract

Propolis-based therapeutic agents represent this potential for the development of new drugs in dental care. The aim of a clinical-cohort study was to determine the influence of application of toothpaste enriched with Brazilian extract of propolis (EEP) on health status of oral cavity. Laboratory analysis was conducted in order to assess the chemical composition of EEP including total phenolic compounds, the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, ABTS radical cation scavenging activity, and FRAP assay. Clinical research involved two groups of subjects comprising 32 adult patients, with assessment based on the preliminary evaluation of the state of their marginal periodontium. The investigation of oral health indices API, OHI, and SBI and microbiological examination of oral microflora were also carried out. Results obtained indicated time-dependent microbial action of EEP at 50 mg/L concentration, with antimicrobial activity against Gram-positive bacteria. The total decrease of API, OHI, and SBI mean values was observed. Hygienic preparations with 3% content of Brazilian ethanol extract of green propolis (EEP) efficiently support removal of dental plaque and improve the state of marginal periodontium.

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Figures

Figure 1
Figure 1
The kill curve of standard microorganisms strains, which indicated the time-dependent antimicrobial activity of the EEP (used concentration of EEP was 50 mg/L).
Figure 2
Figure 2
The kill curve of Streptococcus mutans (a) and Lactobacillus acidophilus (b) standard strains, which indicated the time-dependent antimicrobial activity of the EEP (used concentrations of EEP were: 10 mg/L, 20 mg/L and 50 mg/L).
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