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. 2013 Sep 14;11(34):5579-83.
doi: 10.1039/c3ob40887f.

Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

Roger A Ashmus  1 , Nathaniel S Schocker, Yanira Cordero-Mendoza, Alexandre F Marques, Erika Y Monroy, Andrew Pardo, Luis Izquierdo, Montserrat Gállego, Joaquim Gascon, Igor C Almeida, Katja Michael
Affiliations

Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

Roger A Ashmus et al. Org Biomol Chem. .

Abstract

A synthetic glycoarray containing non-reducing α-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi was evaluated by a chemiluminescent enzyme-linked immunosorbent assay with sera from patients with chronic Chagas disease. Our data revealed the disaccharide Galα(1,3)Galβ as the immunodominant glycotope, which may eventually be employed as a diagnostic antigen for Chagas disease.

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