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. 2013 Aug;5(4):309-15.
doi: 10.4021/jocmr1489w. Epub 2013 Jun 21.

Efficacy of vitamin C vaginal tablets as prophylaxis for recurrent bacterial vaginosis: a randomised, double-blind, placebo-controlled clinical trial

Vladislav N Krasnopolsky  1 , Vera N Prilepskaya, Franco Polatti, Nina V Zarochentseva, Guldana R Bayramova, Maurizio Caserini, Renata Palmieri
Affiliations

Efficacy of vitamin C vaginal tablets as prophylaxis for recurrent bacterial vaginosis: a randomised, double-blind, placebo-controlled clinical trial

Vladislav N Krasnopolsky et al. J Clin Med Res. 2013 Aug.

Abstract

Background: The aetiology of bacterial vaginosis (BV) is still unclear but it is currently considered to be a synergistic polymicrobial syndrome. BV can often arise as a chronic or recurrent disease. The reason for such recurrences is not well elucidated. Previous studies have suggested that vaginal vitamin C may be a useful treatment in reducing recurrence rate, by increasing vaginal acidification and thereby making up for the decrease in hydrogen peroxide that results from a reduction in the number of lactobacilli present. Based on the above-mentioned consideration, a study was performed that aimed to evaluate the effect of vitamin C in the prophylaxis of BV relapses.

Methods: This was a randomised, double-blind, placebo-controlled, parallel-group clinical trial. One hundred and forty-two women, after having been cured from a recent episode of BV by either metronidazole or clindamycin, were randomised to receive vitamin C (74 patients) or placebo (68 patients) as prophylaxis for six monthly cycles, starting within 24 hours of the determination of 'BV cure'. The patients applied one vaginal tablet once a day for 6 consecutive days per month after menses.

Results: The rate of BV recurrence during the first 3 months was considerably lower in the vitamin C group (6.8%) than in the placebo (14.7%) group. Considering a 6-month treatment period, the recurrence rate in the vitamin C group (16.2%) was significantly lower (P = 0.024) than in the placebo group (32.4%). Moreover, at the same time point, the survival analysis of Kaplan Meyer was significant in favour of the vitamin C group compared with the placebo group (P = 0.029).

Conclusions: The study showed that regular use of 250 mg ascorbic acid vaginal tablets on 6 days per month for 6 months after successful treatment of bacterial vaginosis halves the risk of recurrence from 32.4% to 16.2% (P = 0.024).

Keywords: Ascorbic acid vaginal tablets; Bacterial vaginosis; Bacterial vaginosis prophylaxis; Vitamin C vaginal tablets.

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Figures

Figure 1
Figure 1
Proportion of patients free of BV relapse after three-cycle and six-cycle periods of prophylaxis (Intention-to-treat population, n = 142).
Figure 2
Figure 2
Kaplan-Meier survival analysis after six-cycle period of prophylaxis (Intention-to-treat population, n = 142).
Figure 3
Figure 3
(a). Vaginal pH-lowering effect of vitamin C; (b): Vaginal pH-lowering effect of placebo.
See this image and copyright information in PMC

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