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. 2013 Jul 17:13:664.
doi: 10.1186/1471-2458-13-664.

Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces

Ling Qiu  1 , Xin-qi Cheng, Jie Wu, Jun-ting Liu, Tao Xu, Hai-tao Ding, Yan-hong Liu, Zeng-mei Ge, Ya-jing Wang, Hui-juan Han, Jing Liu, Guang-jin Zhu
Affiliations

Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces

Ling Qiu et al. BMC Public Health. .

Abstract

Background: Hyperuricemia (HUA) is a potential risk factor for developing insulin resistance, hypertension, dyslipidemia and cardiovascular disease. Therefore, we studied the prevalence of HUA and associated risk factors in the population of two provinces in northern China.

Methods: Based on the research of Chinese Physiological Constant and Health Conditions conducted in 2008-2010, we enrolled 29,639 subjects in a randomized, stratified study in four sampling areas in Heilongjiang Province and the Inner Mongolia Autonomous Region. We collected 13,140 serum samples to determine biochemical indicators including uric acid(UA), glucose, blood lipids, liver function, and renal function, and finally a representative sample of 8439 aged 18 years and older was determined. We also defined and stratified HUA, hypertension, diabetes, obesity and lipid abnormalities according to international guidelines.

Results: There were significant differences in the UA levels between different genders and regions. The total prevalence of HUA is 13.7%. Men had a higher prevalence of HUA than women (21% vs. 7.9%; P < 0.0001). As age increased, HUA prevalence decreased in men but rose in women. The suburbs of big cities had the highest HUA prevalence (18.7%), and in high-prevalence areas the proportion of women with HUA also increased. A stepwise logistic regression model was used to filter out twelve HUA risk factors, including age, gender, residence, hypercholesterolemia, hypertriglyceridemia, impaired fasting glucose, hypertension, obesity, abdominal obesity, CKD, drinking and sleeping. After adjusting for these factors, the odds ratio of HUA was 1.92 times higher in men than in women. Compared with agricultural and pastoral areas, the odds ratio of having HUA was 2.14 for participants in the suburbs of big cities and 1.57 in the center of big cities.

Conclusions: The prevalence of HUA is high in northern China. The differences in HUA prevalence by geographic region suggested that unbalanced economic development and health education, therefore HUA prevention measures should be strengthened to improve quality of life and reduce health care costs.

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Figures

Figure 1
Figure 1
The proportion of male and female in areas with different HUA prevalence.
See this image and copyright information in PMC

References

    1. Lin KC, Lin HY, Chou P. The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J Rheumatol. 2000;27(6):1501–1505. - PubMed
    1. Vuorinen-Markkola H, Yki-Jarvinen H. Hyperuricemia and insulin resistance. J Clin Endocrinol Metab. 1994;78(1):25–29. doi: 10.1210/jc.78.1.25. - DOI - PubMed
    1. Causevic A, Semiz S, Macic Dzankovic A, Cico B, Dujic T, Malenica M, Bego T. Relevance of uric acid in progression of type 2 diabetes mellitus. Bosn J Basic Med Sci. 2010;10(1):54–59. - PMC - PubMed
    1. Hwu CM, Lin KH. Uric acid and the development of hypertension. Med Sci Monit. 2010;16(10):RA224–RA230. - PubMed
    1. Gagliardi AC, Miname MH, Santos RD. Uric acid: a marker of increased cardiovascular risk. Atherosclerosis. 2009;202(1):11–17. doi: 10.1016/j.atherosclerosis.2008.05.022. - DOI - PubMed

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