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Review
. 2014;6(1):13-20.
doi: 10.1159/000353588. Epub 2013 Jul 18.

Interactions between human immunodeficiency virus type 1 and polymorphonuclear neutrophils

Sarah Casulli  1 , Carole Elbim
Affiliations
Review

Interactions between human immunodeficiency virus type 1 and polymorphonuclear neutrophils

Sarah Casulli et al. J Innate Immun. 2014.

Abstract

Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal infections. However, it is now clear that the relationship between PMN and HIV-1 is far more complex. This review examines both the beneficial and the detrimental effects of PMN during HIV infection.

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Figures

Fig. 1
Fig. 1
Summary of the different facets of the interactions between PMN and HIV-1, i.e. the role of PMN in the control of HIV-1 infection, the role of PMN in HIV-1 transmission, the dysregulation of PMN functions and survival in HIV-infected patients, and the effects of HAART on PMN functions and survival.
See this image and copyright information in PMC

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