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. 2013 Aug 20;109(4):844-51.
doi: 10.1038/bjc.2013.404. Epub 2013 Jul 18.

Cerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma

M Karremann  1 , U Rausche, D Roth, A Kühn, T Pietsch, G H Gielen, M Warmuth-Metz, R-D Kortmann, R Straeter, A Gnekow, J E A Wolff, C M Kramm
Affiliations

Cerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma

M Karremann et al. Br J Cancer. .

Abstract

Background: High-grade glioma (HGG) of the cerebellum accounts for only 5% of paediatric HGG. Since little is known about these tumours, the present study aimed at their further characterisation.

Methods: Twenty-nine paediatric patients with centrally reviewed cerebellar HGG were identified from the HIT-GBM/HIT-HGG database. Clinical and epidemiological data were compared with those of 180 paediatric patients with cortical HGG.

Results: Patients with cerebellar tumours were younger (median age of 7.6 vs 11.7 years, P=0.028), but both groups did not differ significantly with regard to gender, tumour predisposing syndromes, secondary HGG, primary metastasis, tumour grading, extent of tumour resection, chemotherapy regimen, or radiotherapy. Except for an increased incidence of anaplastic pilocytic astrocytoma (APA) in the cerebellar subset (20.7% vs 3.3%; P<0.001), histological entities were similarly distributed in both groups. As expected, tumour grading had a prognostic relevance on survival. Compared with cortical HGG, overall survival in the cerebellar location was significantly worse (median overall survival: 0.92 ± 0.02 vs 2.03 ± 0.32 years; P=0.0064), and tumour location in the cerebellum had an independent poor prognostic significance as shown by Cox-regression analysis (P=0.019).

Conclusion: High-grade glioma represents a group of tumours with an obviously site-specific heterogeneity associated with a worse survival in cerebellar location.

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Figures

Figure 1
Figure 1
Kaplan–Meier analysis of overall survival in paediatric patients with high-grade glioma of the cerebral cortex (n=180) and the cerebellum (n=29).
Figure 2
Figure 2
Kaplan–Meier analysis of overall survival in paediatric patients with GBM of the cerebral cortex (n=96) and the cerebellum (n=17).
See this image and copyright information in PMC

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