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Review
. 2013 Sep;10(3):190-7.
doi: 10.1007/s11897-013-0149-5.

Acute heart failure with preserved ejection fraction: unique patient characteristics and targets for therapy

Kalkidan Bishu  1 , Margaret M Redfield
Affiliations
Review

Acute heart failure with preserved ejection fraction: unique patient characteristics and targets for therapy

Kalkidan Bishu et al. Curr Heart Fail Rep. 2013 Sep.

Abstract

Currently, there are 1.0 million annual hospital discharges for acute heart failure (AHF). The total cost of heart failure (HF) care in the United States is projected to increase to $53 billion in 2030, with the majority of costs (80 %) related to AHF hospitalizations. Approximately 50 % of AHF episodes occur in patients with preserved ejection fraction (HFpEF). There is a dearth of evidence-based guidelines for the management of AHF in HFpEF patients. Here, we briefly review the epidemiology, pathophysiology, and treatment of AHF patients with HFpEF.

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Conflict of interest statement

Compliance with Ethics Guidelines

Conflict of Interest Kalkidan Bishu declares that he has no conflict of interest.

Figures

Fig. 1
Fig. 1
Unique pathophysiology in HFpEF determines hemodynamic response to acute vasodilator therapy: Grouped data from pressure volume analysis in patients with heart failure (HF) with preserved (HFpEF) or reduced (HFrEF) ejection fraction. Patients with HFpEF have higher end systolic elastance (Ees), indicating greater left-ventricular systolic stiffness. Equivalent reduction in total arterial load (arterial elastance, Ea) was achieved with acute administration of nitrosprusside in the two forms of HF. In response to vasodilatation, HFpEF patients experienced greater reduction in arterial pressure but less increase in stroke volume. (Reprinted from Schwartzenberg S, Redfield MM, From AM, Sorajja P, Nishimura RA, Borlaug BA, Effects of Vasodilation in Heart Failure With Preserved or Reduced Ejection Fraction. Journal of the American College of Cardiology. 2012; 59(5):442–451. ©2012, with permission from Elsevier)
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References

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