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Randomized Controlled Trial
. 2013 Nov;51(3):749-53.
doi: 10.1007/s12031-013-0058-9. Epub 2013 Jul 19.

The effect of vitamin A supplementation on retinoic acid-related orphan receptor γt (RORγt) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients

Niyaz Mohammadzadeh Honarvar  1 , Mohammad Hossein Harirchian, Fariba Koohdani, Feridoun Siassi, Mina Abdolahi, Sama Bitarafan, Eisa Salehi, Mohammad Ali Sahraian, Mohammad Reza Eshraghian, Ali Akbar Saboor-Yarghi
Affiliations
Randomized Controlled Trial

The effect of vitamin A supplementation on retinoic acid-related orphan receptor γt (RORγt) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients

Niyaz Mohammadzadeh Honarvar et al. J Mol Neurosci. 2013 Nov.

Abstract

The aim of this study was to investigate the role of vitamin A on RORγt and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and RORγt gene expression. No changes in gene expression occurred in the placebo group.

Trial registration: ClinicalTrials.gov NCT01225289.

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References

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