Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Dec;41(12):1249-52.
doi: 10.1016/j.ajic.2013.04.003. Epub 2013 Jul 17.

Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

Yuriko Fukuta  1 , Robert R Muder, Mounzer E Agha, Lloyd G Clarke, Marilyn M Wagener, Amelia M Hensler, Yohei Doi
Affiliations

Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

Yuriko Fukuta et al. Am J Infect Control. 2013 Dec.

Abstract

Background: Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited.

Methods: We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii.

Results: A total of 31 case patients were matched with 62 control patients. Hematologic malignancy (P = .036), need for dialysis (P = .01), admission for other reasons except elective surgery (P = .03), transfer from other health care facilities (P = .02), prolonged intensive care unit stay (P = .004), mechanical ventilation (P < .001), pressor use (P = .001), tube feeding (P < .001), transfusion (P = .009), and prior antimicrobial use (P < .001) were identified as significant risk factors in univariate analysis. Need for dialysis (odds ratio [OR], 18.23; P = .04) and prolonged intensive care unit stay (OR, 19.28; P = .01) remained significant in multivariate analysis. Lengths of stay were 28 days for the case patients and 10 days for the control patients (P = .001). The 90-day mortality rates were 41.9% and 29.0%, respectively (P = .20).

Conclusions: Acquisition of MDR A baumannii among cancer patients appears to be associated with general nosocomial infection risk factors rather than underlying malignancies.

Keywords: Case-control study; Clinical outcome; Colonization; Infection; Malignancy.

PubMed Disclaimer

Publication types