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Comparative Study
. 2013 Oct 1;62(14):1280-1287.
doi: 10.1016/j.jacc.2013.05.078. Epub 2013 Jul 17.

Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis)

Chia-Ying Liu  1 , Yuan-Chang Liu  2 , Colin Wu  3 , Anderson Armstrong  4 , Gustavo J Volpe  4 , Rob J van der Geest  5 , Yongmei Liu  6 , William G Hundley  7 , Antoinette S Gomes  8 , Songtao Liu  9 , Marcelo Nacif  1 , David A Bluemke  10 , João A C Lima  11
Affiliations
Comparative Study

Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis)

Chia-Ying Liu et al. J Am Coll Cardiol. .

Abstract

Objectives: This study sought to determine the relationship of cardiovascular magnetic resonance (CMR) measures of tissue composition to age in the Multi-Ethnic Study of Atherosclerosis (MESA).

Background: Animal and human studies have demonstrated increased collagen deposition in senescent hearts. New CMR indices of tissue composition by using T1 mapping are sensitive to the presence of myocardial fibrosis.

Methods: A total of 1,231 study participants (51% women; age range 54 to 93 years) of the MESA cohort were evaluated with T1 mapping by using 1.5-T CMR scanners. None of the participants had focal scar on delayed enhancement CMR. Single-slice T1 mapping was performed at the midventricular level before and at 12- and 25-min delay after administration of gadolinium contrast by using a modified Look-Locker inversion recovery sequence. The partition coefficient was determined by the slope of the linear relationship of (1/T1myo vs. 1/T1blood). The extracellular volume fraction (ECV) was derived accounting for the hematocrit level. Multivariable regression analyses were performed, adjusting for traditional risk factors and left ventricular structure.

Results: Women had significantly greater partition coefficient, ECV, and precontrast T1 than men, as well as lower post-contrast T1 values (all p < 0.05). In general, linear regression analyses demonstrated that greater partition coefficient, pre-contrast T1 values, and ECV were associated with older age in men (multivariate regression coefficients = 0.01; 5.9 ms; and 1.04% per 10 years' change; all p < 0.05). ECV was also significantly associated with age in women after multivariable adjustments.

Conclusions: CMR parameters that have been associated with myocardial fibrosis were related to older age in the MESA study. Women had higher ECV than men but less ECV change over time.

Keywords: BMI; CMR; ECV; GFR; Gd; LV; MOLLI; MR; T(1) mapping; aging; body mass index; cardiovascular magnetic resonance; extracellular volume; gadolinium; glomerular filtration rate; left ventricular; magnetic resonance; magnetic resonance imaging; modified Look-Locker inversion recovery; myocardial fibrosis.

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Figures

Figure 1
Figure 1. Partition Coefficient and ECV in Age Categories
The mean (A) partition coefficient and (B) extracellular volume (ECV) fraction in each age category stratified according to sex. *p < 0.05 between women and men.
Figure 2
Figure 2. Associations Between Age and ECV
Regression plot between age and extracellular volume fraction (ECV) in all cohorts after adjustments for all covariables in model 3.
See this image and copyright information in PMC

Comment in

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