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Review
. 2013 Oct;100(1):20-8.
doi: 10.1016/j.antiviral.2013.07.007. Epub 2013 Jul 18.

Crimean-Congo hemorrhagic fever in Iran

Maryam Keshtkar-Jahromi  1 , Mohammad M Sajadi, Hossein Ansari, Masoud Mardani, Kourosh Holakouie-Naieni
Affiliations
Review

Crimean-Congo hemorrhagic fever in Iran

Maryam Keshtkar-Jahromi et al. Antiviral Res. 2013 Oct.

Abstract

The presence of Crimean-Congo hemorrhagic fever virus (CCHFV) in Iran was first identified in studies of livestock sera and ticks in the 1970s, but the first human infection was not diagnosed until 1999. Since that time, the number of cases of CCHF in Iran has markedly increased. Through January 2012, articles in the published literature have reported a total of 870 confirmed cases, with 126 deaths, for a case fatality rate (CFR) of 17.6%. The disease has been seen in 26 of the country's 31 provinces, with the greatest number of cases in Sistan and Baluchestan, Isfahan, Fars, Tehran, Khorasan, and Khuzestan provinces. The increase in CCHF in Iran has paralleled that in neighboring Turkey, though the number of cases in Turkey has been much larger, with an overall CFR of around 5%. In this article, we review the features of CCHF in Iran, including its history, epidemiology, animal and tick reservoirs, current surveillance and control programs, diagnostic methods, clinical features and experience with ribavirin therapy, and consider possible explanations for the difference in the CFR of CCHF between Iran and Turkey. The emergence of CCHF in Iran calls for countermeasures at many levels to protect the population, but also provides opportunities for studying the epidemiology, diagnosis and management of the disease.

Keywords: Arbovirus; Crimean Congo hemorrhagic fever; Iran; Ribavirin; Tick-borne disease.

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Figures

Figure 1
Figure 1
Total number of cases of CCHF reported by each province in Iran, over the period 2000–12. Data were obtained from the Pasteur Institute of Iran and from (Chinikar et al., 2012).
Figure 2
Figure 2
Total number of confirmed CCHF cases in Iran and Turkey reported each year for the period 2000–12, with the total number of fatal cases in Iran. Data were obtained from the Pasteur Institute of Iran and from (Chinikar, et al., 2012; Yilmaz et al., 2008; Ergonul, 2009; Maltezou et al., 2010; Burki, 2012).
See this image and copyright information in PMC

References

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