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Comment
. 2013 Aug;94(2):198-200.
doi: 10.1038/clpt.2013.116.

Genetics of cisplatin ototoxicity: confirming the unexplained?

A V Boddy  1
Affiliations
Comment

Genetics of cisplatin ototoxicity: confirming the unexplained?

A V Boddy. Clin Pharmacol Ther. 2013 Aug.

Abstract

Replication of findings in clinical pharmacogenetic studies is essential but often neglected. The observation that TPMT and COMT genotypes, in combination with ABCC3 genotype, are predictive of ototoxicity following cisplatin treatment has been confirmed. However, translating this observation into a useful preventive strategy requires more mechanistic insight.

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