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Clinical Trial
. 2014 Feb;16(1):127-35.
doi: 10.1007/s11307-013-0670-7.

Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma

Takaaki Beppu  1 , Kazunori Terasaki, Toshiaki Sasaki, Shunrou Fujiwara, Hideki Matsuura, Kuniaki Ogasawara, Koichiro Sera, Noriyuki Yamada, Noriyuki Uesugi, Tamotsu Sugai, Kohsuke Kudo, Makoto Sasaki, Shigeru Ehara, Ren Iwata, Yoshihiro Takai
Affiliations
Clinical Trial

Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma

Takaaki Beppu et al. Mol Imaging Biol. 2014 Feb.

Abstract

Purpose: The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[(18)F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole ((18)F-FRP170).

Procedures: Twelve patients with glioblastoma underwent (18)F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of (18)F-FRP170. In these areas, intratumoral oxygen pressure (tpO2) was measured using microelectrodes during tumor resection.

Results: Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area.

Conclusion: The present findings suggest that high accumulation on (18)F-FRP170 PET represents viable hypoxic tissues in glioblastoma.

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