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. 1990 Aug 20;269(1):181-4.
doi: 10.1016/0014-5793(90)81149-i.

Cloning of the human brain GABA transporter

H Nelson  1 , S Mandiyan, N Nelson
Affiliations
Free article

Cloning of the human brain GABA transporter

H Nelson et al. FEBS Lett. .
Free article

Abstract

A cDNA clone encoding a transporter for the neurotransmitter gamma-aminobutyric acid in human brain was cloned and sequenced. The cDNA contains an open reading frame encoding a hydrophobic protein of 599 amino acids with a calculated molecular weight of 67022 Da. Hydropathy analysis revealed twelve potential transmembrane segments. The human protein is highly homologous to the protein from rat brain. Northern hybridization demonstrated a ubiquitous distribution of the transporter in various parts of the brain.

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