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. 2013 Sep;13(9):1225-8.
doi: 10.1517/14712598.2013.822484. Epub 2013 Jul 23.

Efficacy of omalizumab in chronic spontaneous urticaria refractory to conventional therapy: analysis of 110 patients in real-life practice

Moises Labrador-Horrillo  1 , Antonio Valero, Manuel Velasco, Ignacio Jáuregui, Joaquin Sastre, Joan Bartra, Juan Francisco Silvestre, Javier Ortiz de Frutos, Ana Gimenez-Arnau, Marta Ferrer
Affiliations

Efficacy of omalizumab in chronic spontaneous urticaria refractory to conventional therapy: analysis of 110 patients in real-life practice

Moises Labrador-Horrillo et al. Expert Opin Biol Ther. 2013 Sep.

Abstract

Objective: To collect data on the efficacy and safety of omalizumab in 110 patients from 9 Spanish hospitals suffering from chronic spontaneous urticaria (CSU) refractory to conventional treatment.

Methods: A retrospective, descriptive analysis was performed, showing the data of 110 patients suffering from refractory CSU who received omalizumab as an off-label treatment in 9 Spanish hospitals from October 2009 to September 2012.

Results: Ninety (81.8%) patients exhibited a complete or significant response, 12 (10.9%) had partial response, and 8 (7.2%) showed no response. Sixty-six (60%) patients were able to stop all concomitant medications, remaining asymptomatic treated with omalizumab alone. No serious adverse events were reported.

Conclusions: Omalizumab shows excellent efficacy and safety profile in a large series of CSU patients in real-life practice. This drug will contribute to settle the debt with CSU patients contributing to restore their quality of life.

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