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Review
. 2013 Nov;74(11):1486-90.
doi: 10.1016/j.humimm.2013.07.001. Epub 2013 Jul 19.

Moving beyond HLA: a review of nHLA antibodies in organ transplantation

Tara K Sigdel  1 , Minnie M Sarwal
Affiliations
Review

Moving beyond HLA: a review of nHLA antibodies in organ transplantation

Tara K Sigdel et al. Hum Immunol. 2013 Nov.

Abstract

Given the finite graft life expectancy of HLA identical organ transplants and the recognition of humoral graft injury in the absence of donor directed anti-HLA antibodies, the clinical impact of antibodies against non-HLA (nHLA) antigens in transplant injury is being increasingly recognized. The recognition of the impact of nHLA antigen discrepancies between donor and recipient on transplant outcomes is timely given the advances in rapid and lower cost sequencing methods that can soon provide complete maps of all recipient and donor HLA and nHLA mismatch data. In this review, we present a summary of recent reports evaluating the role of nHLA antibodies and their relevance to the field of organ transplantation.

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References

    1. Nankivell BJ, Alexander SI. Rejection of the kidney allograft. N Engl J Med. 2010;363(15):1451. - PubMed
    1. Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med. 1969;280(14):735. - PubMed
    1. Lefaucheur C, Suberbielle-Boissel C, Hill GS, Nochy D, Andrade J, Antoine C, et al. Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation. Am J Transplant. 2008;8(2):324. - PubMed
    1. Terasaki PI. A personal perspective: 100-year history of the humoral theory of transplantation. Transplantation. 2012;93(8):751. - PubMed
    1. Zeevi A, Lunz J, Feingold B, Shullo M, Bermudez C, Teuteberg J, et al. Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody- mediated rejection in heart transplant recipients. J Heart Lung Transplant. 2012;32(1):98. - PMC - PubMed

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