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. 2013 Aug;19(8):1281-4.
doi: 10.3201/eid1908.121455.

Macrolide resistance of Mycoplasma pneumoniae, South Korea, 2000-2011

Ki Bae Hong  1 , Eun Hwa Choi, Hoan Jong Lee, Seong Yeon Lee, Eun Young Cho, Jae Hong Choi, Hyun Mi Kang, Jina Lee, Young Min Ahn, Yeon-Ho Kang, Joon-Ho Lee
Affiliations

Macrolide resistance of Mycoplasma pneumoniae, South Korea, 2000-2011

Ki Bae Hong et al. Emerg Infect Dis. 2013 Aug.

Abstract

In Korea, Mycoplasma pneumoniae was detected in 255/2,089 respiratory specimens collected during 2000-2011; 80 isolates carried 23S rRNA gene mutations, and 69/123 culture-positive samples with the mutation were resistant to 5 macrolides. During 2000-2011, prevalence of the mutation increased substantially. These findings have critical implications for the treatment of children with mycoplasma pneumonia.

Keywords: Mycoplasma pneumoniae; South Korea; macrolide; pneumonia; resistance; respiratory infections; tuberculosis and other mycobacteria.

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Figures

Figure
Figure
Increased prevalence of macrolide resistance of Mycoplasma pneumoniae strains isolated from children during epidemics of lower respiratory tract infections, South Korea, 2000–2011. During the 2000 epidemic, 0 of 30 strains were resistant, but during the epidemics of 2003 and 2006, 1 of 34 and 10 of 68 strains, respectively, showed resistance. During the 2010–2011 outbreak, 25 of 53 (2010) and 44 of 70 (2011) strains were resistant. Numbers on the bars are the percentages of resistant strains for each year.
See this image and copyright information in PMC

References

    1. Matsuoka M, Narita M, Okazaki N, Ohya H, Yamazaki T, Ouchi K, et al. Characterization and molecular analysis of macrolide-resistant Mycoplasma pneumoniae clinical isolates obtained in Japan. Antimicrob Agents Chemother. 2004;48:4624–30. 10.1128/AAC.48.12.4624-4630.2004 - DOI - PMC - PubMed
    1. Atkinson TP, Balish MF, Waites KB. Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMS Microbiol Rev. 2008;32:956–73. 10.1111/j.1574-6976.2008.00129.x - DOI - PubMed
    1. Eun BW, Kim NH, Choi EH, Lee HJ. Mycoplasma pneumoniae in Korean children: the epidemiology of pneumonia over an 18-year period. J Infect. 2008;56:326–31. 10.1016/j.jinf.2008.02.018 - DOI - PubMed
    1. Morozumi M, Iwata S, Hasegawa K, Chiba N, Takayanagi R, Matsubara K, et al. Increased macrolide resistance of Mycoplasma pneumoniae in pediatric patients with community-acquired pneumonia. Antimicrob Agents Chemother. 2008;52:348–50. 10.1128/AAC.00779-07 - DOI - PMC - PubMed
    1. Peuchant O, Menard A, Renaudin H, Morozumi M, Ubukata K, Bebear CM, et al. Increased macrolide resistance of Mycoplasma pneumoniae in France directly detected in clinical specimens by real-time PCR and melting curve analysis. J Antimicrob Chemother. 2009;64:52–8. 10.1093/jac/dkp160 - DOI - PubMed

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