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. 2013 Jul;126(14):2705-9.

Effect of c-Met inhibitor SU11274 on human colon cancer cell growth

Shuo-hui Gao  1 , Chao Liu, Jun Wei, Ye Feng
Affiliations
  • PMID: 23876900

Effect of c-Met inhibitor SU11274 on human colon cancer cell growth

Shuo-hui Gao et al. Chin Med J (Engl). 2013 Jul.

Abstract

Background: Colon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy. Downregulation of HGF/c-Met signaling pathway is an emerging therapy for cancer treatment.

Methods: In this study, the inhibitory effects of c-Met phosphorylation were observed with SU11274 on different colon cancer cell lines in vitro.

Results: The results revealed the significant inhibitory effects of SU11274 on cell proliferation and cell survival, in a time and dose-dependent manner. Furthermore, the inhibitory effects of SU11274 on different subgroups of colon cancer cells via the HGF/c-Met signaling pathway were implicated in this study.

Conclusion: The results suggested the possible selective therapeutic effects of c-Met inhibitor on colon cancer.

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