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Comment
. 2013 Jul 22;202(2):187-9.
doi: 10.1083/jcb.201306152.

Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis

Mohan K Balasubramanian  1 , Evelyn Yaqiong Tao
Affiliations
Comment

Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis

Mohan K Balasubramanian et al. J Cell Biol. .

Abstract

In many eukaryotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction and new membrane organization. Two studies in this issue (Onishi et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201302001 and Atkins et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201301090) establish that precise activation and/or inactivation of Rho1 and Cdc42 GTPases is important for the correct order and successful completion of events downstream of actomyosin ring constriction in budding yeast.

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Figures

Figure 1.
Figure 1.
The highs and lows of Rho1 and Cdc42 during the cell cycle. Activity profiles of Rho1 and Cdc42 through the budding yeast cell cycle and the proposed functions for activation and inactivation of Rho1 and Cdc42. P1, P2, and T1 refer to peak 1, peak 2, and trough 1, respectively, of the activity of the GTPases described. PS and SS refer to primary septum and secondary septum, respectively. MEN refers to the mitotic exit network signaling module.
See this image and copyright information in PMC

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References

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