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. 2014 Apr;16(4):357-65.
doi: 10.1111/hpb.12142. Epub 2013 Jul 24.

Laparoscopic resection of hepatocellular carcinoma: a French survey in 351 patients

Olivier Soubrane  1 , Claire Goumard, Alexis Laurent, Hadrien Tranchart, Stéphanie Truant, Brice Gayet, Chadi Salloum, Guillaume Luc, Safi Dokmak, Tullio Piardi, Daniel Cherqui, Ibrahim Dagher, Emmanuel Boleslawski, Eric Vibert, Antonio Sa Cunha, Jacques Belghiti, Patrick Pessaux, Pierre-Yves Boelle, Olivier Scatton
Affiliations

Laparoscopic resection of hepatocellular carcinoma: a French survey in 351 patients

Olivier Soubrane et al. HPB (Oxford). 2014 Apr.

Abstract

Objectives: Current clinical studies report the results of laparoscopic resection of hepatocellular carcinoma (HCC) obtained in small cohorts of patients. Because France was involved in the very early development of laparoscopic surgery, the present study was conducted in order to report the results of a large, multicentre experience.

Methods: A total of 351 patients underwent laparoscopic liver resection for HCC during the period from 1998 to 2010 in nine French tertiary centres. Patient characteristics, postoperative mortality and morbidity, and longterm survival were retrospectively reviewed.

Results: Overall, 85% of the study patients had underlying liver disease. Types of resection included wedge resection (41%), left lateral sectionectomy (27%), segmentectomy (24%), and major hepatectomy (11%). Median operative time was 180 min. Conversion to laparotomy occurred in 13% of surgeries and intraoperative blood transfusion was necessary in 5% of patients. The overall morbidity rate was 22%. The 30-day postoperative mortality rate was 2%. Negative resection (R0) margins were achieved in 92% of patients. Rates of overall and progression-free survival at 1, 3 and 5 years were 90.3%, 70.1% and 65.9%, and 85.2%, 55.9% and 40.4%, respectively.

Conclusions: This multicentre, large-cohort study confirms that laparoscopic liver resection for HCC is a safe and efficient approach to treatment and can be proposed as a first-line treatment in patients with resectable HCC.

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Figures

Figure 1
Figure 1
Aetiologies of underlying liver disease in patients submitted to laparoscopic liver resection for hepatocellular carcinoma. HBV, hepatitis B virus; HCV, hepatitis C virus; NASH, non-alcoholic steatohepatitis
Figure 2
Figure 2
Annual incidences of laparoscopic liver resection for hepatocellular carcinoma in nine French tertiary centres during 1998–2010
Figure 3
Figure 3
Overall survival (OS) and progression-free survival (PFS) in 351 patients submitted to laparoscopic liver resection for hepatocellular carcinoma during 1998–2010
Figure 4
Figure 4
Overall survival (OS) and progression-free survival (PFS) in 63 patients with good prognoses submitted to laparoscopic liver resection for hepatocellular carcinoma during 1998–2010
See this image and copyright information in PMC

References

    1. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet. 2003;362:1907–1917. - PubMed
    1. Yoo HY, Patt CH, Geschwind JF, Thuluvath PJ. The outcome of liver transplantation in patients with hepatocellular carcinoma in the United States between 1987 and 2001: 5-year survival has improved significantly with time. J Clin Oncol. 2003;21:4329–4335. - PubMed
    1. Cherqui D, Laurent A, Mocellin N, Tayar C, Luciani A, Van Nhieu JT, et al. Liver resection for transplantable hepatocellular carcinoma. Longterm results and role of secondary liver transplantation. Ann Surg. 2009;250:738–746. - PubMed
    1. Scatton O, Zalinski S, Terris B, Lefevre JH, Casali A, Massault PP, et al. Hepatocellular carcinoma developed on compensated cirrhosis: resection as a selection tool for liver transplantation. Liver Transpl. 2008;14:779–788. - PubMed
    1. Lacy AM, Garcia-Valdecasas JC, Delgado S, Castells A, Taurá P, Piqué JM, et al. Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomized trial. Lancet. 2002;359:2224–2229. - PubMed

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