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. 2013 Jun;6(6):31-7.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome

Sonal Choudhary  1 , Michael McLeod, Daniele Torchia, Paolo Romanelli
Affiliations

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome

Sonal Choudhary et al. J Clin Aesthet Dermatol. 2013 Jun.

Abstract

Drug rash with eosinophilia and systemic symptoms syndrome is a severe idiosyncratic drug reaction with a long latency period. It has been described using many terms; however, drug rash with eosinophilia and systemic symptoms syndrome appears to be the most appropriate. This syndrome causes a diverse array of clinical symptoms, anywhere from 2 to 8 weeks after initiating the offending drug. Standardized criteria for the diagnosis have been developed; however, their utility remains to be validated. Unfortunately, the management of drug rash with eosinophilia and systemic symptoms syndrome is not well supported by strong evidence-based data.

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Figures

Figures 1A and 1B
Figures 1A and 1B
Erythematous scaly patch with papules on forearm (A). Desquamation of soles. Upon closer inspection, petechiae were visible (B).
Figure 2
Figure 2
Parakeratosis, intracorneal neutrophilic pustule, spongiosis, and mixed perivascular infiltrate (Hematoxylin and eosin stain; original magnification: ×200.)
See this image and copyright information in PMC

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