Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Jul 16;2(2).
doi: 10.3402/jchimp.v2i2.17718. Print 2012.

Vitamin C-induced oxalate nephropathy: a case report

Harmeet Gurm  1 , Mohamed Ali Sheta, Noel Nivera, Allan Tunkel
Affiliations
Case Reports

Vitamin C-induced oxalate nephropathy: a case report

Harmeet Gurm et al. J Community Hosp Intern Med Perspect. .

Abstract

Therapeutic benefits of vitamin C is an area of active research and large doses have been suggested by many studies for treatment of various conditions. We are describing a case of oxalate nephropathy leading to end stage kidney disease, which occurred secondary to mega-dose of oral vitamin C. Increasing the awareness between medical personnel as well as patients will clearly decrease the incidence of this debilitating but, at the same time, highly preventable disease.

Keywords: acute kidney injury; oxalate nephropathy; vitamin C.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
H&E Slide showing multiple tubular distention by a clear crystalline material with mild to moderate mononuclear inflammation.
Fig. 2
Fig. 2
Polarized oxalate in tubules (A and B).
See this image and copyright information in PMC

References

    1. Dietary Reference Intakes: applications in dietary Assessment. Food and Nutrition Board. Washington, DC: National Academy Press; 2000. pp. 284–9.
    1. Roll S, Nocon M, Willich SN. Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: A randomized, double-blind, placebo-controlled trial. Br J Nutr. 2011;105:118–22. - PMC - PubMed
    1. McRae M. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: A meta-analysis of 13 randomized controlled trials. J Chiropr Med. 2008;7:48–58. - PMC - PubMed
    1. Choi HK, Gao X, Curhan G, Vitamin C. Intake and the risk of gout in men – a prospective study. Arch Intern Med. 2009;169:502–7. - PMC - PubMed
    1. Bagnasco S, Mohammed BS, Mani H, Gandolfo MT, Haas M, Racusen LC, et al. Oxalate deposits in biopsies from native and transplanted kidneys, and impact on graft function. Nephrol Dial Transplant. 2009;24:1319–25. - PubMed

Publication types

LinkOut - more resources