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Comment
. 2013 Jul 24;5(195):195fs29.
doi: 10.1126/scitranslmed.3006850.

When killers become helpers

Umesh S Deshmukh  1 , Harini Bagavant
Affiliations
Comment

When killers become helpers

Umesh S Deshmukh et al. Sci Transl Med. .

Abstract

Interplay between a natural killer (NK)-cell receptor, NKp30, and other cells in the salivary glands profoundly affects pathogenesis of the autoimmune disease Sjögren's syndrome (Rusakiewicz et al., this issue).

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1. Other little helper
(Left) In lymph nodes that drain the salivary glands, NK cells interact with DCs carrying apoptotic debris from SGECs, resulting in DC maturation. Mature DCs interact with and activate T cells, which then couple with and activate B cells, thus initiating the systemic autoimmune response. (Right) Within the salivary glands, NKp30-expressing NK cells interact with SGECs that express B7-H6. This interaction leads to the production of multiple chemokines, which spurs inflammatory cell infiltration within the salivary gland. NK-activated DCs interact with infiltrating T cells. The resulting activated T cells couple with and activate B cells, which produce autoantibodies and thus initiate and sustain a localized autoimmune response. IL-12, interleukin-12.
See this image and copyright information in PMC

Comment on

  • NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome.
    Rusakiewicz S, Nocturne G, Lazure T, Semeraro M, Flament C, Caillat-Zucman S, Sène D, Delahaye N, Vivier E, Chaba K, Poirier-Colame V, Nordmark G, Eloranta ML, Eriksson P, Theander E, Forsblad-d'Elia H, Omdal R, Wahren-Herlenius M, Jonsson R, Rönnblom L, Nititham J, Taylor KE, Lessard CJ, Sivils KL, Gottenberg JE, Criswell LA, Miceli-Richard C, Zitvogel L, Mariette X. Rusakiewicz S, et al. Sci Transl Med. 2013 Jul 24;5(195):195ra96. doi: 10.1126/scitranslmed.3005727. Sci Transl Med. 2013. PMID: 23884468 Free PMC article.

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