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. 2013 Jun 13;3(1):95-6.
doi: 10.1159/000351988. Print 2013 Jan.

Reversal of Vitamin K Antagonist Therapy by Prothrombin Complex Concentrate before Thrombolysis for Acute Stroke

Nicolas Chausson  1 , Manvel Aghasaryan, Djibril Soumah, Tony Altarcha, Didier Smadja
Affiliations

Reversal of Vitamin K Antagonist Therapy by Prothrombin Complex Concentrate before Thrombolysis for Acute Stroke

Nicolas Chausson et al. Cerebrovasc Dis Extra. .
No abstract available

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References

    1. Haeusler KG, Konieczny M, Endres M, Villringer A, Heuschmann PU. Impact of anticoagulation before stroke on stroke severity and long-term survival. Int J Stroke. 2012;7:544–550. - PubMed
    1. Xian Y, Liang L, Smith EE, et al. Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator. JAMA. 2012;307:2600–2608. - PubMed
    1. Pfeilschifter W, Spitzer D, Pfeilschifter J, Steinmetz H, Foerch C. Warfarin anticoagulation exacerbates the risk of hemorrhagic transformation after rt-PA treatment in experimental stroke: therapeutic potential of PCC. PLoS One. 2011;6:e26087. - PMC - PubMed
    1. Leissinger CA, Blatt PM, Hoots WK, Ewenstein B. Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature. Am J Hematol. 2008;83:137–143. - PubMed
    1. Sun L, Zhou W, Ploen R, Heiland S, Zorn M, Veltkamp R. Rapid reversal of anticoagulation prevents excessive secondary hemorrhage after thrombolysis in a thromboembolic model in rats. Stroke. 2011;42:3524–3529. - PubMed

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