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. 2013 Aug;19(8):1231-8.
doi: 10.3201/eid1908.130458.

Effects and clinical significance of GII.4 Sydney norovirus, United States, 2012-2013

Eyal Leshem  1 , Mary Wikswo, Leslie Barclay, Eric Brandt, William Storm, Ellen Salehi, Traci DeSalvo, Tim Davis, Amy Saupe, Ginette Dobbins, Hillary A Booth, Christianne Biggs, Katie Garman, Amy M Woron, Umesh D Parashar, Jan Vinjé, Aron J Hall
Affiliations

Effects and clinical significance of GII.4 Sydney norovirus, United States, 2012-2013

Eyal Leshem et al. Emerg Infect Dis. 2013 Aug.

Abstract

During 2012, global detection of a new norovirus (NoV) strain, GII.4 Sydney, raised concerns about its potential effect in the United States. We analyzed data from NoV outbreaks in 5 states and emergency department visits for gastrointestinal illness in 1 state during the 2012-13 season and compared the data with those of previous seasons. During August 2012-April 2013, a total of 637 NoV outbreaks were reported compared with 536 and 432 in 2011-2012 and 2010-2011 during the same period. The proportion of outbreaks attributed to GII.4 Sydney increased from 8% in September 2012 to 82% in March 2013. The increase in emergency department visits for gastrointestinal illness during the 2012-13 season was similar to that of previous seasons. GII.4 Sydney has become the predominant US NoV outbreak strain during the 2012-13 season, but its emergence did not cause outbreak activity to substantially increase from that of previous seasons.

Keywords: GII.4 Sydney strain; United States; enteric infections; norovirus; outbreak; surveillance; viruses.

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Figures

Figure 1
Figure 1
Number of suspected and confirmed norovirus gastroenteritis outbreaks by week of illness onset: Minnesota, Ohio, Oregon, Tennessee, and Wisconsin, August 1, 2010–April 16, 2013 (no. outbreaks = 1,605).
Figure 2
Figure 2
Genotypes of confirmed norovirus gastroenteritis outbreaks in Minnesota, Ohio, Oregon, Tennessee, and Wisconsin, August 1, 2012–April 16, 2013 (no. outbreaks = 358). *Data available for outbreaks during April 1, 2013–April 16, 2013.
Figure 3
Figure 3
Percentage of emergency department and urgent care (ED) visits for gastrointestinal illness as reported through the Ohio EpiCenter syndromic surveillance system and number of suspected and confirmed norovirus gastroenteritis outbreaks by week, August 1, 2010–April 16, 2013.
See this image and copyright information in PMC

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