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. 1990 Sep;10(9):4970-3.
doi: 10.1128/mcb.10.9.4970-4973.1990.

The mouse ribosomal DNA promoter has more stringent requirements in vivo than in vitro

S L Henderson  1 , B Sollner-Webb
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The mouse ribosomal DNA promoter has more stringent requirements in vivo than in vitro

S L Henderson et al. Mol Cell Biol. 1990 Sep.

Abstract

Using mouse ribosomal DNA templates bearing polymerase I terminators to prevent transcriptional interference (S. L. Henderson, K. Ryan, and B. Sollner-Webb, Genes Dev. 3:212-223, 1989) and facilitate promoter analysis in intact cells, we demonstrate that a -140 promoter domain (as well as the core region) is essential for appreciable levels of initiation in vivo. This in vivo polymerase I promoter can also be detected in vitro but only under very stringent conditions.

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References

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