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. 2013 Jul 23:4:208.
doi: 10.3389/fmicb.2013.00208. eCollection 2013.

Resistance in tuberculosis: what do we know and where can we go?

Keith D Green  1 , Sylvie Garneau-Tsodikova
Affiliations

Resistance in tuberculosis: what do we know and where can we go?

Keith D Green et al. Front Microbiol. .

Abstract

Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.

Keywords: antibiotics; inhibitors; mechanisms of resistance; new drug targets; synergistic drug therapy.

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Figures

Figure 1
Figure 1
(A) Structures of the anti-TB drugs discussed in this mini-review. (B) Schematic representation of the three methodologies explored to overcome resistance in Mtb.
See this image and copyright information in PMC

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