Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Jun 7;5(2):85-8.
doi: 10.4081/rt.2013.e23. Print 2013 Apr 15.

Primary diffuse large B-cell lymphoma of the ascending colon

Aram Barbaryan  1 , Alaa M Ali, Shawn G Kwatra, Raya Saba, Suartcha Prueksaritanond, Nasir Hussain, Aibek E Mirrakhimov, Natalya Vladimirskiy, Teresita Zdunek, Alan D Gilman
Affiliations
Case Reports

Primary diffuse large B-cell lymphoma of the ascending colon

Aram Barbaryan et al. Rare Tumors. .

Abstract

Primary colorectal lymphoma is a rare malignancy accounting for 3% of all gastrointestinal lymphomas and 0.1-0.5% of all colorectal malignancies. Among primary colorectal lymphomas, the most common histological subtype of colorectal lymphoma is diffuse large B-cell lymphoma. We report a case of an 84-year old Caucasian female who was admitted to the hospital because of a 2 days history of altered mental status. In the emergency department the patient was found to have acute kidney injury and hypercalcemia. On physical examination a large lower quadrant abdominal mass was palpated. Computed tomography scan of abdomen confirmed the presence of a mass along the cecum and proximal ascending colon. Colonoscopy showed a large ulcerated mass and biopsy was consistent with diffuse large B-cell lymphoma. The patient underwent colectomy but refused to receive chemotherapy.

Keywords: abdominal mass; diffuse large B-cell lymphoma; gastrointestinal lymphoma; hypercalcemia; lymphoma.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Large circumferential mass along the cecum and ascending colon measuring 12.7×7.7×12.1 cm in size with oral contrast within the lumen.
Figure 2.
Figure 2.
Colonoscopy-ulcerating ascending colon mass.
Figure 3.
Figure 3.
Surgical specimen from ascending colon showing bowel wall infiltration with tumor tissue.
Figure 4.
Figure 4.
Diffuse sheets of large atypical lymphoid cells with prominent nucleoli.
Figure 5.
Figure 5.
Effacement of normal colonic architecture by a diffuse infiltrate of lymphoid cells.
Figure 6.
Figure 6.
Immunohistochemistry: peroxidase staining shows the tumor cells to be positive for CD20, a pan B cell marker.
See this image and copyright information in PMC

References

    1. Palli D, Trallori G, Bagnoli S, et al. Hodgkin's disease risk is increased in patients with ulcerative colitis. Gastroenterology 2000;119:647-53 - PubMed
    1. Paryani S, Hoppe RT, Burke JS, et al. Extralymphatic involvement in diffuse non-Hodgkin's lymphoma. J Clin Oncol 1983;1:682-8 - PubMed
    1. Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Ann Oncol 2008;19:1992-9 - PMC - PubMed
    1. Loehr WJ, Mujahed Z, Zahn FD, et al. Primary lymphoma of the gastrointestinal tract: a review of 100 cases. Ann Surg 1969;170:232-8 - PMC - PubMed
    1. Doolabh N, Anthony T, Simmang C, et al. Primary colonic lymphoma. J Surg Oncol 2000;74:257-62 - PubMed

Publication types

LinkOut - more resources