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Review
. 2013 Jun;5(6):1180-1201.
doi: 10.3390/toxins5061180.

Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis

Fabrizio Vinante  1 , Antonella Rigo
Affiliations
Review

Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis

Fabrizio Vinante et al. Toxins (Basel). 2013 Jun.

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological and pathological processes spanning from proliferation and apoptosis to morphogenesis. We outline here the main activities of HB-EGF in connection with normal or neoplastic differentiative or proliferative events taking place primitively in the hematopoietic microenvironment.

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Figures

Figure 1
Figure 1
Basic structure, functional domains, and processing of HB-EGF.
Figure 2
Figure 2
HB-EGF network relevant to hematopoietic niche. Cell-to-cell interactions and gradients of cell-shed factors, including CXCL12 and HB-EGF, lock both hematopoietic and stromal stem cells in the hematopoietic niche where they support each other to keep surviving as undifferentiated cells. Hematopoietic differentiation implies both asymmetric hematopoietic stem cell mitosis and maturing progenitor escape from the niche microenvironment partly due to receptor modulation.
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