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Comment
. 2013 Jul 25;39(1):94-6.
doi: 10.1016/j.immuni.2013.07.010.

RNA helicase DHX33 puts a new twist on NLRP3 inflammasome activation

Igor E Brodsky  1
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RNA helicase DHX33 puts a new twist on NLRP3 inflammasome activation

Igor E Brodsky. Immunity. .
Free article

Abstract

The mechanisms by which NLRP3 senses inflammasome-activating stimuli remain poorly defined. In this issue of Immunity, Mitoma et al. (2013) demonstrate that the RNA helicase DHX33 binds to cytosolic dsRNAs to trigger NLRP3 inflammasome activation.

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