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. 2014 Apr;17(4):827-32.
doi: 10.1017/S1368980013001675. Epub 2013 Jul 26.

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Li Chang  1 , Xiaojuan Liu  1 , Hua Shi  1 , Wei Dai  1 , Hong Wang  1 , Yongmei Jiang  1
Affiliations

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Li Chang et al. Public Health Nutr. 2014 Apr.

Abstract

Objective: To evaluate the prevalence of vitamin D deficiency and insufficiency, as well as their association with Hb and elevated blood lead levels (BLL) in children in China.

Design: A cross-sectional and 1-year retrospective study.

Setting: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China.

Subjects: Children aged from 6 months to 14 years living in south-west China who were taken to physical examinations (January-December 2011).

Results: Of 1218 children included in the study, 25-hydroxyvitamin D (25(OH)D) concentration (mean 33.18 (sd 16.48) ng/ml) was deficient in 21.6% and insufficient in 27.4%, which were higher than the prevalence of both anaemia at 8.5% and elevated BLL (Pb ≥ 10 μg/dl) at 1.8%, but lower than mildly elevated BLL prevalence (5 μg/dl ≤ Pb < 10 μg/dl) at 56.9%. There was a negative correlation between 25(OH)D concentration and BLL (r = -0.216, P < 0.001) while no significant relationship was found between 25(OH)D concentration and Hb (r = -0.012, P > 0.05). After multivariable adjustment, the significant predictors of 25(OH)D deficiency and insufficiency were increasing child age especially between 8 and 14 years (OR = 18.29; 95% CI 10.14, 32.99; P < 0.001) and BLL (OR = 1.01; 95% CI 1.00, 1.02; P = 0.045).

Conclusions: The prevalence of 25(OH)D deficiency and insufficiency was much higher than that of anaemia or elevated BLL in south-west China, and associated with increasing age and BLL.

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Figures

Fig. 1
Fig. 1
The correlations between vitamin D status, measured as serum 25-hydroxyvitamin D (25(OH)D) level, and Hb and blood lead levels (BLL) among 1218 children aged from 6 months to 14 years, south-west China, 2011. (a) Two-way scatterplot of vitamin D status and Hb level shows there is no correlation (r = −0·012, P = 0·669); (b) two-way scatterplot of vitamin D status and BLL shows a negative correlation (r = −0·216, P < 0·001)
See this image and copyright information in PMC

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