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Review
. 2013 Dec;25(6):704-10.
doi: 10.1016/j.ceb.2013.07.004. Epub 2013 Jul 24.

Dynamic regulation of ubiquitin-dependent cell cycle control

Allison Craney  1 , Michael Rape
Affiliations
Review

Dynamic regulation of ubiquitin-dependent cell cycle control

Allison Craney et al. Curr Opin Cell Biol. 2013 Dec.

Abstract

Recent work revealed that cullin-RING ligases and the anaphase-promoting complex, two classes of ubiquitin ligases that are essential for cell division in all eukaryotes, are regulated in a highly dynamic manner. Here, we describe mechanisms that establish the dynamic regulation of these crucial ubiquitylation enzymes and discuss the functional consequences for cell division control.

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