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. 2013 Sep;23(9):571-5.
doi: 10.1016/j.annepidem.2013.06.006. Epub 2013 Jul 23.

Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Hannah Arem  1 , Susan T Mayne, Joshua Sampson, Harvey Risch, Rachael Z Stolzenberg-Solomon
Affiliations

Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Hannah Arem et al. Ann Epidemiol. 2013 Sep.

Abstract

Purpose: Epidemiologic and experimental studies suggest that dietary fat intake may affect risk of pancreatic cancer, but published results are inconsistent.

Methods: We examined risk associations for specific types of dietary fat intakes and related food sources among 111,416 participants in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We used Cox proportional hazards regression to examine associations between fat intake and pancreatic cancer risk.

Results: Over a mean 8.4 years of follow-up, 411 pancreatic cancer cases were identified. We observed an inverse association between saturated fat intake and pancreatic cancer risk (hazard ratio [HR], 0.64 comparing extreme quintiles; 95% confidence interval [CI], 0.46-0.88), but the association became weaker and nonsignificant when individuals with fewer than 4 years of follow-up were excluded to avoid possible reverse causation (HR, 0.88; 95% CI, 0.58-1.33). Total fat intake showed a similar pattern of association, whereas intakes of monounsaturated and polyunsaturated fats and fats from animal or plant sources showed no associations with risk.

Conclusions: These results do not support the hypothesis of increased pancreatic cancer risk with higher fat consumption overall or by specific fat type or source. Dietary changes owing to undetected disease may explain the observed inverse association with saturated fat.

Keywords: Cohort studies; Dietary fats; Epidemiology; Pancreatic neoplasms.

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References

    1. What is pancreatic cancer? : American Cancer Society. [cited 2011 August 11];2011 Available from: http://www.cancer.org/cancer/pancreaticcancer/detailedguide/pancreatic-c....
    1. Roebuck BD, Yager JD, Jr, Longnecker DS, Wilpone SA. Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat. Cancer Res. 1981 Oct;41(10):3961–3966. - PubMed
    1. Roebuck BD, Yager JD, Jr, Longnecker DS. Dietary modulation of azaserine-induced pancreatic carcinogenesis in the rat. Cancer Res. 1981 Mar;41(3):888–893. - PubMed
    1. Birt DF, Salmasi S, Pour PM. Enhancement of experimental pancreatic cancer in Syrian golden hamsters by dietary fat. J Natl Cancer Inst. 1981 Dec;67(6):1327–1332. - PubMed
    1. Thiébaut ACM, Jiao L, Silverman DT, Cross AJ, Thompson FE, Subar AF, et al. Dietary fatty acids and pancreatic cancer in the NIH-AARP Diet and Health Study. J Natl Cancer Inst. 2009. 2009 Jul 15;101(14):1001–1011. - PMC - PubMed

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