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Comment
. 2013 Aug;45(8):847-9.
doi: 10.1038/ng.2706.

MAPping the genomic landscape of low-grade pediatric gliomas

Sevin Turcan, Timothy A Chan
Comment

MAPping the genomic landscape of low-grade pediatric gliomas

Sevin Turcan et al. Nat Genet. 2013 Aug.

Abstract

Two recent large-scale sequencing studies have identified multiple genetic aberrations in pediatric low-grade gliomas. These findings offer substantial insights that may spur the development of new diagnostics and treatments for these cancers.

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Figures

Figure 1
Figure 1
The majority of genetic alterations in pediatric LGGs activate the MAPK-ERK pathway. MAPK pathway components with alterations identified in the studies by Zhang et al. and Jones et al. are indicated with red stars. Several factors linked to histone modification were also found to have genetic abnormalities in a small subset of samples (dashed box). These findings offer insight into novel approaches to targeted therapeutics for pediatric LGGs.
See this image and copyright information in PMC

Comment on

  • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
    Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project. Jones DT, et al. Nat Genet. 2013 Aug;45(8):927-32. doi: 10.1038/ng.2682. Epub 2013 Jun 30. Nat Genet. 2013. PMID: 23817572 Free PMC article.

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