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. 2013 Aug 26;52(35):9309-12.
doi: 10.1002/anie.201304401. Epub 2013 Jul 24.

Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo

John A McIntosh  1 , Pedro S Coelho, Christopher C Farwell, Z Jane Wang, Jared C Lewis, Tristan R Brown, Frances H Arnold
Affiliations

Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo

John A McIntosh et al. Angew Chem Int Ed Engl. .
No abstract available

Keywords: CH activation; cytochromes; enzyme catalysis; protein engineering; synthetic biology.

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Figures

Figure 1
Figure 1
Substrate selectivity of P411 enzymes compared with free hemin. Compounds used to test the dependence of amination activity on C-H bond strength in reactions catalyzed by enzyme (0.1 mol%) or hemin (1 mol%) are shown. Reaction conditions described in supporting information.
Scheme 1
Scheme 1
Initial reaction screening substrate and products
See this image and copyright information in PMC

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