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Meta-Analysis
. 2013 Jul 19;8(7):e68527.
doi: 10.1371/journal.pone.0068527. Print 2013.

Prognostic value of Ezrin in solid tumors: a meta-analysis of the literature

Kun Han  1 , WeiXiang Qi, ZhiHua Gan, Zan Shen, Yang Yao, DaLiu Min
Affiliations
Meta-Analysis

Prognostic value of Ezrin in solid tumors: a meta-analysis of the literature

Kun Han et al. PLoS One. .

Abstract

Purpose: Ezrin is a cytoskeletal protein involved in tumor growth and invasion. However its prognostic value for survival in patients with solid tumor remains controversial.

Methods: Several databases were searched, including Pubmed, Embase and Cochrane databases. The endpoints were overall survival (OS), progression-free survival (PFS). The pooled hazard ratio (HR) or odds ratio (OR), and 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials.

Results: Twenty-seven eligible trials involving 4693 patients were ultimately identified. A summary hazard ratio (HR) of all studies and sub-group hazard ratios were calculated. The combined HR suggested that a positive Ezrin expression had an impact on overall survival (OS) [1.95, 95% confidence interval (CI) 1.60-2.39; P<0.001] in all eligible studies and progress free survival (PFS): (2.30 95% CI 1.0-3.61; P = 0.001). Similar results were also observed in subgroup analysis, according to tumor types, regions, patients' number and publication year.

Conclusions: Our findings suggested that Ezrin protein expression might be a factor for a poor prognosis in patients with solid tumor. So large well-designed prospective studies are now needed to confirm the clinical utility of Ezrin as an independent prognostic marker.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Methodological Flow Chart of the Systematic.
Figure 2
Figure 2. Ezrin expression and OS.
Figure 3
Figure 3. Ezrin expression and PFS.
Figure 4
Figure 4. Begg's test result of OS.
Figure 5
Figure 5. Egger's test result of OS.
See this image and copyright information in PMC

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