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. 2013 Jun 1;2(6):e24521.
doi: 10.4161/onci.24521. Epub 2013 Apr 16.

The role of FOXP3 in disease progression in colorectal cancer patients

Tanja Grimmig  1 , Mia Kim, Christoph-Thomas Germer, Martin Gasser, Ana Maria Waaga-Gasser
Affiliations

The role of FOXP3 in disease progression in colorectal cancer patients

Tanja Grimmig et al. Oncoimmunology. .

Abstract

The transcription factor forkhead box P3 (FOXP3) has been identified as a marker of CD4+CD25+ regulatory T cells and is a key determinant of their immunosuppressive functions. FOXP3 has indeed been shown to limit antitumor immune responses during tumor progression. In addition, by expressing FOXP3, tumor cells may evade effector T-cell responses.

Keywords: FOXP3; colorectal cancer; prognosis.

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Figures

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Figure 1. Impact of FOXP3 on oncogenesis and tumor progression. Immunosuppressive cytokines such as interleukin-10 (IL-10) and transforming growth factor β (TGFβ) released by either FOXP3+ regulatory T cells (Tregs) or FOXP3+ cancer cells inhibit the activation of naive T cells, hence limiting antitumor immune responses and favoring oncogenesis and tumor progression.
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