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Review
. 2013;27(10):1124-33.
doi: 10.3109/02699052.2013.801513. Epub 2013 Jul 29.

Treatment for depression following mild traumatic brain injury in adults: a meta-analysis

Suzanne Barker-Collo  1 , Nicola Starkey, Alice Theadom
Affiliations
Review

Treatment for depression following mild traumatic brain injury in adults: a meta-analysis

Suzanne Barker-Collo et al. Brain Inj. 2013.

Abstract

Primary objective: Development of depression after TBI is linked to poorer outcomes. The aim of this manuscript is to review evidence for the effectiveness of current treatments.

Research design: Two meta-analyses were undertaken to examine the effectiveness of both pharmacological and non-pharmacological interventions for depression after mild TBI.

Method and procedures: PubMed, Medline, PsychInfo, Web of Science and Digital Dissertations were searched and 13 studies located. Meta Analyst Beta 3.13 was used to conduct analyses of pre- vs post-effects then to examine treatment group vs control group effects.

Main outcomes and results: Studies using a pre-post design produced an overall effect size of 1.89 (95% CI = 1.20-2.58, p < 0.001), suggesting that treatments were effective; however, the overall effect for controlled trials was 0.46 (95% CI = -0.44-1.36, p < 0.001), which favoured the control rather than treatment groups.

Conclusions: This study highlights the need for additional large well-controlled trials of effective treatments for depression post-TBI.

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