[A comparative evaluation of the efficacy of different therapeutic methods in sarcoidosis of the skin]

Abstract

Twenty-eight patients with skin sarcoidosis were treated with thymalin, thymogen, levamisole, dimocifon, with due consideration for their immune status. Immunostimulating therapy has failed. Plaquenil, phthivazide and duplex therapy did not result in noticeable improvement either. An individual pattern of mononuclear phagocyte response to various immunoregulators was revealed. The highest sensitivity to human interferon, hydrocortisone, and prospidine was determined in vitro. The highest effect was achieved by a combination of corticosteroids with prospidine, though in 20 percent of cases the disease recurred within 2 years. Since these drugs are not harmless for the body, the major indications for their prescription to patients with skin sarcoidosis (provided there are no direct indications because of other conditions) are the process activity and dissemination, cosmetic defects because of the disease. In case of a local involvement and uneventful course of the process a follow-up is advisable.