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Multicenter Study
. 2013 Nov;163(5):1503-6.e1.
doi: 10.1016/j.jpeds.2013.06.025. Epub 2013 Jul 26.

Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates

Ulrika Adén  1 , Aiping Lin, Waldemar Carlo, Alan Leviton, Jeffrey C Murray, Mikko Hallman, Richard P Lifton, Heping Zhang, Laura R Ment; Gene Targets for Intraventricular Hemorrhage Study Group
Collaborators, Affiliations
Multicenter Study

Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates

Ulrika Adén et al. J Pediatr. 2013 Nov.

Abstract

Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.

Keywords: AGA; Appropriate for gestational age; BW; Birth weight; COL4A1; Collagen 4A1; Gr; Grade; IL; IVH; Interleukin; Intraventricular hemorrhage; MTHFR; Methylenetetrahydrofolate reductase; TNF; Tumor necrosis factor.

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Conflict of interest statement

The other authors declare no conflicts of interest.

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