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Review
. 2013 Aug;31(3):799-808.
doi: 10.1016/j.ncl.2013.03.007. Epub 2013 Apr 4.

Surgical treatment of Parkinson disease: past, present, and future

Andrew P Duker  1 , Alberto J Espay
Affiliations
Review

Surgical treatment of Parkinson disease: past, present, and future

Andrew P Duker et al. Neurol Clin. 2013 Aug.

Abstract

Advances in functional neurosurgery have expanded the treatment of Parkinson disease (PD) to targeted electrical stimulation of specific nodes in the basal ganglia circuitry. Deep brain stimulation (DBS), applied to selected patients and difficult-to-manage motor fluctuations, yields substantial reductions in off time and dyskinesia. Emerging concepts in DBS include examination of new targets, such as the potential efficacy of pedunculopontine nucleus stimulation for treatment of freezing and falls, the use of pathologic oscillations in the beta band to construct an adaptive "closed-loop" DBS, and new technologies, including segmented electrodes to steer current toward specific neural populations.

Keywords: Beta band oscillations; Deep brain stimulation; Parkinson disease; Patient selection.

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Figures

Figure 1
Figure 1
Decision-making algorithm for patient selection for DBS surgery in Parkinson’s disease.
Figure 2
Figure 2
Intraoperative placement of the DBS electrode.
See this image and copyright information in PMC

References

    1. Leriche Ueber Chirurgischen Eingriff bei Parkinson’s scher Krankheit. Neurologische Zeitblaetter. 1912;13:1093–1096.
    1. Klemme RM. Surgical treatment of dystonia, paralysis agitans and athetosis. Arch Neurol Pysch. 1940;44:926.
    1. Putnam TJ. Relief from unilateral paralysis agitans by section of the pyramidal tract. Arch Neurol. 1938;40:1049–1050.
    1. Walker AE. Cerebral pedunculotomy for the relief of involuntary movements. II. Parkinsonian tremor. J Nerv Ment Dis. 1952 Dec;116(6):766–775. - PubMed
    1. Meyers R. Surgical experiments in the therapy of certain “extrapyramidal” diseases: a current evaluation. Acta Psychiatr Neurol Suppl. 1951;67:1–42. - PubMed

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