Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jul 26;14(8):15681-94.
doi: 10.3390/ijms140815681.

Impaired pre-mRNA processing and altered architecture of 3' untranslated regions contribute to the development of human disorders

Eva Michalova  1 , Borivoj Vojtesek, Roman Hrstka
Affiliations
Review

Impaired pre-mRNA processing and altered architecture of 3' untranslated regions contribute to the development of human disorders

Eva Michalova et al. Int J Mol Sci. .

Abstract

The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3' untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3' UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3' UTRs may contribute to the development of various disorders in humans.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Crick F. Central dogma of molecular biology. Nature. 1970;227:561–563. - PubMed
    1. Zhao J., Hyman L., Moore C. Formation of mrna 3′ ends in eukaryotes: Mechanism, regulation, and interrelationships with other steps in mrna synthesis. Microbiol. Mol. Biol. Rev. 1999;63:405–445. - PMC - PubMed
    1. Lemay J.F., Lemieux C., St-Andre O., Bachand F. Crossing the borders: Poly(a)-binding proteins working on both sides of the fence. RNA Biol. 2010;7:291–295. - PubMed
    1. Proudfoot N.J., Brownlee G.G. 3′ non-coding region sequences in eukaryotic messenger rna. Nature. 1976;263:211–214. - PubMed
    1. Matoulkova E., Michalova E., Vojtesek B., Hrstka R. The role of the 3′ untranslated region in post-transcriptional regulation of protein expression in mammalian cells. RNA Biol. 2012;9:563–576. - PubMed

Publication types

MeSH terms

Supplementary concepts