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Review
. 2013 Sep;30(9):1158-64.
doi: 10.1039/c3np70051h. Epub 2013 Jul 30.

From micrograms to grams: scale-up synthesis of eribulin mesylate

Melvin J Yu  1 , Wanjun Zheng, Boris M Seletsky
Affiliations
Review

From micrograms to grams: scale-up synthesis of eribulin mesylate

Melvin J Yu et al. Nat Prod Rep. 2013 Sep.

Abstract

The synthesis of eribulin mesylate from microgram to multi-gram scale is described in this Highlight. Key coupling reactions include formation of the C30a to C1 carbon-carbon bond and macrocyclic ring closure through an intramolecular Nozaki-Hiyama-Kishi reaction.

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