Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug;140(2):248-52.
doi: 10.1309/AJCPMF3B9XJAKXKM.

Tissue response to bovine fetal collagen extracellular matrix in full-thickness skin wounds

James S A Neill  1 , William C Lineaweaver
Affiliations

Tissue response to bovine fetal collagen extracellular matrix in full-thickness skin wounds

James S A Neill et al. Am J Clin Pathol. 2013 Aug.

Abstract

Objectives: To present the findings of the biological response and assimilation of bovine fetal collagen (BFC) as observed in biopsy specimens taken after implant.

Methods: The biopsy specimens were from 9 patients with full-thickness skin wounds who received the BFC biomaterial in the first stage of a 2-stage reconstruction. Biopsy specimens were taken at the second stage of skin grafting from the wound margins.

Results: The response to the BFC included neovascularization and infiltration of the collagen matrix with fibroblasts. The acellular matrix had the tinctural properties of devitalized tissue, which may be mistaken for coagulative necrosis if one is unaware of the biomaterial implant.

Conclusions: The characteristics of BFC histology should be recognized by pathologists involved in patients treated for reconstruction and wound care.

Keywords: Bovine fetal collagen; Dermal substitute; Dermatopathology; Histology; Wound healing.

PubMed Disclaimer

LinkOut - more resources