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Review
. 2013 Aug;14(8):664-9.
doi: 10.1631/jzus.BQICC701.

Interleukin-17 and acute coronary syndrome

Sheng-an Su  1 , Hong Ma, Li Shen, Mei-xiang Xiang, Jian-an Wang
Affiliations
Review

Interleukin-17 and acute coronary syndrome

Sheng-an Su et al. J Zhejiang Univ Sci B. 2013 Aug.

Abstract

Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear, we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism.

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Conflict of interest statement

Compliance with ethics guidelines: Sheng-an SU, Hong MA, Li SHEN, Mei-xiang XIANG, and Jian-an WANG declare that they have no conflict of interest.

This article does not contain any studies with human or animal subjects performed by any of the authors.

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References

    1. Ávalos AM, Apablaza FA, Quiroz M, Toledo V, Peño JP, Michea L, Irarrázabal CE, Carrión FA, Figueroa FE. IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction. Biol Res. 2012;45(2):193–200. - PubMed
    1. Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Cihakova D. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res. 2010;106(10):1646–1655. doi: 10.1161/CIRCRESAHA.109.213157. - DOI - PubMed
    1. Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL. Innate and acquired immunity in atherogenesis. Nat Med. 2002;8(11):1218–1226. doi: 10.1038/nm1102-1218. - DOI - PubMed
    1. Chang SH, Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res. 2007;17(5):435–440. doi: 10.1038/cr.2007.35. - DOI - PubMed
    1. Chen S, Crother TR, Arditi M. Emerging role of IL-17 in atherosclerosis. J Innate Immun. 2010;2(4):325–333. doi: 10.1159/000314626. - DOI - PMC - PubMed

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